We present the first documented case of reactive arthritis (ReA) secondary to sexually acquired Shigella flexneri infection. The case occurred in the context of a recent change in Shigella epidemiology in England where non-travel associated cases are now contributing the majority of diagnoses. Such non-travel associated cases are occurring predominantly in men who have sex with men with high sexual risk taking behaviour reflecting the importance of the sexual history when assessing a man with Shigella infection who has not travelled. We suggest Shigella can be thought of as a cause of sexually acquired ReA and not just a form of enteric ReA. Referral to sexual health services for further management is essential.