Incidence, timing and impact of comorbidity on second hip fracture: a population-based study

ANZ J Surg. 2018 Jun;88(6):577-581. doi: 10.1111/ans.14507. Epub 2018 May 8.

Abstract

Background: To quantify the incidence and timing of second hip fracture, and to evaluate the relative impact of comorbidities on risk of second hip fracture.

Methods: Hospitalization records for individuals aged ≥65, admitted to a New South Wales hospital for fall-related hip fracture between 1 January 2005 and 31 December 2009 were linked. Comorbidities were identified from the records using a 1-year look-back period. To calculate second hip fracture rates, individuals were followed until death, fracture or end of study period (31 December 2012). Time-dependent competing-risk hazards regression was used to assess the relative contribution of each comorbidity to fracture risk, adjusting for age and sex.

Results: Of the 24 500 individuals who sustained at least one hip fracture, 2.9% experienced a second within a year, 6.1% within 3 years and 9.4% within 8 years. Malnutrition/cachexia (hazard ratio (HR): 2.47; 99.9% confidence interval (CI): 1.87-3.26), dementia (HR: 2.15; 99.9% CI: 1.80-2.57), congestive heart failure (HR: 1.62; 99.9% CI: 1.30-2.04), Parkinson's disease (HR: 1.51; 99.9% CI: 1.08-2.10), cerebrovascular disease (HR: 1.41; 99.9% CI: 1.06-1.89) and osteoporosis (HR: 1.36; 99.9% CI: 1.11-1.67) were associated with increased risk of second hip fracture within 3 years. Mortality was high; with 26% of individuals dying within a year, 44.9% within 3 years and 70.2% within 8 years.

Conclusions: One in 11 older individuals with an initial hip fracture sustained a second hip fracture. While the priority is to prevent the first hip fracture, those that have sustained a hip fracture should be seen as a high risk population and be targeted for future falls and fracture prevention strategies.

Keywords: accidental falls; comorbidity; dementia; hip fracture; hospitalizations.

MeSH terms

  • Accidental Falls / statistics & numerical data*
  • Age Distribution
  • Aged
  • Aged, 80 and over
  • Cohort Studies
  • Comorbidity*
  • Databases, Factual
  • Female
  • Follow-Up Studies
  • Hip Fractures / epidemiology*
  • Hip Fractures / surgery*
  • Hospitals, General
  • Humans
  • Incidence
  • Male
  • New South Wales / epidemiology
  • Recurrence
  • Retrospective Studies
  • Risk Assessment
  • Sex Distribution
  • Survival Analysis
  • Time Factors