Integrated stress response and immune cell infiltration in an ibrutinib-refractory mantle cell lymphoma patient following ONC201 treatment

Br J Haematol. 2019 Apr;185(1):133-136. doi: 10.1111/bjh.15271. Epub 2018 May 8.

Authors

Affiliations

¹ Department of Lymphoma/Myeloma, Division of Cancer Medicine, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
² Oncoceutics Inc., Philadelphia, PA, USA.
³ Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.
⁴ Department of Hematopathology, The University of Texas, M. D. Anderson Cancer Center, Houston, TX, USA.
⁵ Department of Pathology and Laboratory Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
⁶ Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.

PMID: 29740811
DOI: 10.1111/bjh.15271

No abstract available

Keywords: Ibrutinib-refractory; ONC201; mantle cell lymphoma.

Publication types

Case Reports
Letter

MeSH terms

Adenine / analogs & derivatives
Agammaglobulinaemia Tyrosine Kinase / antagonists & inhibitors
Aged
Antineoplastic Agents / therapeutic use*
Antineoplastic Combined Chemotherapy Protocols / administration & dosage
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Bendamustine Hydrochloride / administration & dosage
Cyclophosphamide / administration & dosage
Dopamine D2 Receptor Antagonists / pharmacology
Dopamine D2 Receptor Antagonists / therapeutic use*
Doxorubicin / administration & dosage
Drug Resistance, Neoplasm
Drug Substitution
Heterocyclic Compounds, 4 or More Rings / pharmacology
Heterocyclic Compounds, 4 or More Rings / therapeutic use*
Humans
Imidazoles
Lymphocytes, Tumor-Infiltrating / drug effects*
Lymphoma, Mantle-Cell / drug therapy*
Lymphoma, Mantle-Cell / immunology
Male
Molecular Targeted Therapy
Neoplasm Proteins / antagonists & inhibitors
Oligopeptides / administration & dosage
Piperidines
Prednisone / administration & dosage
Protein Kinase Inhibitors / therapeutic use
Pyrazoles / therapeutic use
Pyridines
Pyrimidines / therapeutic use
Rituximab / administration & dosage
Stress, Physiological / drug effects*
Vincristine / administration & dosage

Substances

Antineoplastic Agents
Dopamine D2 Receptor Antagonists
Heterocyclic Compounds, 4 or More Rings
Imidazoles
Neoplasm Proteins
Oligopeptides
Piperidines
Protein Kinase Inhibitors
Pyrazoles
Pyridines
Pyrimidines
ibrutinib
Rituximab
Vincristine
carfilzomib
Doxorubicin
Cyclophosphamide
Bendamustine Hydrochloride
TIC10 compound
Agammaglobulinaemia Tyrosine Kinase
BTK protein, human
Adenine
Prednisone

Supplementary concepts

CHOP protocol