Living Donor Intestinal Transplantation

Ivo G Tzvetanov; Kiara A Tulla; Giuseppe D'Amico; Enrico Benedetti

doi:10.1016/j.gtc.2018.01.008

Living Donor Intestinal Transplantation

Gastroenterol Clin North Am. 2018 Jun;47(2):369-380. doi: 10.1016/j.gtc.2018.01.008. Epub 2018 Apr 4.

Authors

Ivo G Tzvetanov¹, Kiara A Tulla², Giuseppe D'Amico², Enrico Benedetti²

Affiliations

¹ Department of Surgery, University of Illinois at Chicago, 840 South Wood Street, Suite 402, Chicago, IL 60612, USA. Electronic address: Itzveta@uic.edu.
² Department of Surgery, University of Illinois at Chicago, 840 South Wood Street, Suite 402, Chicago, IL 60612, USA.

PMID: 29735030
DOI: 10.1016/j.gtc.2018.01.008

Abstract

Living donor intestinal transplantation (LDIT) has been improved leading to results comparable to those obtained with deceased donors. LDIT should be limited to specific indications and patient selection. The best indication is combined living donor intestinal/liver transplantation in pediatric recipients with intestinal and hepatic failure; the virtual elimination of waiting time may avoid the high mortality experienced by candidates on the deceased waiting list. Potentially, LDIT could be used in highly sensitized recipients to allow the application of de-sensitization protocols. In the case of available identical twins or HLA-identical sibling, LDIT has a significant immunologic advantage and should be offered.

Keywords: Combined living donor intestinal/liver transplantation; Intestinal failure; Living donor small bowel transplantation; Pediatric recipients.

Publication types

Review

MeSH terms

Composite Tissue Allografts
Donor Selection
Humans
Intestinal Diseases / physiopathology
Intestinal Diseases / surgery*
Intestines / transplantation*
Liver Transplantation
Living Donors*
Organ Transplantation / methods
Organ Transplantation / trends
Time Factors
Tissue and Organ Harvesting / methods*
Treatment Outcome
Waiting Lists / mortality