Abstract
Background:
Chemokines play a critical role in orchestrating the distribution and trafficking of neutrophils in homeostasis and disease.
Results:
The CXCR4/CXCL12 chemokine axis has been identified as a central regulator of these processes.
Conclusion:
In this review, we focus on the role of CXCR4/CXCL12 chemokine axis in regulating neutrophil release from the bone marrow and the trafficking of senescent neutrophils back to the bone marrow for clearance under homeostasis and disease. We also discuss the role of CXCR4 in fine-tuning neutrophil responses in the context of inflammation.
Keywords:
CXCR4; clearance; mobilization; neutrophils; retention.
© 2018 The Authors. European Journal of Clinical Investigation published by John Wiley & Sons Ltd on behalf of Stichting European Society for Clinical Investigation Journal Foundation.
MeSH terms
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Animals
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Benzylamines / pharmacology
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Bone Marrow / physiology
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Cell Survival / physiology
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Chemokine CXCL12 / genetics
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Chemokine CXCL12 / physiology
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Cyclams
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HMGB1 Protein / physiology
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Hematologic Agents / pharmacology
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Heterocyclic Compounds / pharmacology
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Homeostasis / physiology*
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Humans
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Imidazoles / pharmacology
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Immunologic Deficiency Syndromes / genetics
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Inflammation / physiopathology
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Mice
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Mutation / physiology
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Neutrophils / drug effects
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Neutrophils / physiology*
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Peptide Fragments / pharmacology
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Primary Immunodeficiency Diseases
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Receptors, CXCR4 / antagonists & inhibitors
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Receptors, CXCR4 / physiology*
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Serum Albumin / pharmacology
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Spleen / physiology
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Warts / genetics
Substances
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Benzylamines
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Chemokine CXCL12
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Cyclams
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EPI-X4 peptide, human
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HMGB1 Protein
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Hematologic Agents
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Heterocyclic Compounds
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Imidazoles
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N,N-dipropyl-N'-(4-((((1H-imidazol-2-yl)methyl)((1-methyl-1H-imidazol-2-yl) methyl)amino)methyl)benzyl)-N'-methylbutane-1,4-diamine
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Peptide Fragments
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Receptors, CXCR4
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Serum Albumin
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plerixafor