An Overview of Targeted Alpha Therapy with 225Actinium and 213Bismuth

Curr Radiopharm. 2018;11(3):200-208. doi: 10.2174/1874471011666180502104524.

Abstract

Background: Recent reports of the remarkable therapeutic efficacy of 225Ac-labeled PSMA- 617 for therapy of metastatic castration-resistant prostate cancer have underlined the clinical potential of targeted alpha therapy.

Objective and conclusion: This review describes methods for the production of 225Ac and its daughter nuclide 213Bi and summarizes the current clinical experience with both alpha emitters with particular focus on recent studies of targeted alpha therapy of bladder cancer, brain tumors, neuroendocrine tumors and prostate cancer.

Keywords: Targeted alpha therapy; actinium-225; alpha emitter; bismuth-213; clinical application; nuclide production..

Publication types

  • Review

MeSH terms

  • Actinium / chemistry
  • Actinium / pharmacology*
  • Alpha Particles / therapeutic use*
  • Bismuth / chemistry
  • Bismuth / pharmacology*
  • Clinical Trials as Topic
  • Humans
  • Neoplasms / radiotherapy*
  • Radiochemistry / methods
  • Radioimmunotherapy / methods*
  • Radioisotopes / chemistry
  • Radioisotopes / pharmacology*
  • Radiopharmaceuticals / chemistry
  • Radiopharmaceuticals / pharmacology*

Substances

  • Actinium-225
  • Bismuth-213
  • Radioisotopes
  • Radiopharmaceuticals
  • Actinium
  • Bismuth