A mitochondria-selective near-infrared-emitting fluorescent dye for cellular imaging studies

Peter Choi; Katsuya Noguchi; Munetaka Ishiyama; William A Denny; Jiney Jose

doi:10.1016/j.bmcl.2018.05.001

A mitochondria-selective near-infrared-emitting fluorescent dye for cellular imaging studies

Bioorg Med Chem Lett. 2018 Jun 15;28(11):2013-2017. doi: 10.1016/j.bmcl.2018.05.001. Epub 2018 May 3.

Authors

Peter Choi¹, Katsuya Noguchi², Munetaka Ishiyama², William A Denny¹, Jiney Jose³

Affiliations

¹ Auckland Cancer Society Research Centre, School of Medical Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.
² Dojindo Laboratories Co., Ltd, Techno-Research Park Tabaru 2025-5 Mashiki-machi, Kamimashiki-gun, 861-2202, Japan.
³ Auckland Cancer Society Research Centre, School of Medical Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand. Electronic address: j.jose@auckland.ac.nz.

PMID: 29731365
DOI: 10.1016/j.bmcl.2018.05.001

Abstract

This communication details the synthesis, evaluation of photophysical properties, and cellular imaging studies of cyanine chromophore based fluorescent dye 1 as a selective imaging agent for mitochondria.

Keywords: Amoxapine; Cyanine dye; Mitochondria; Near infrared fluorescent dyes; Organelle selective fluorescent dyes.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Carbocyanines / chemical synthesis
Carbocyanines / chemistry*
Carbocyanines / pharmacology
Cell Survival / drug effects
Dose-Response Relationship, Drug
Fluorescent Dyes / chemical synthesis
Fluorescent Dyes / chemistry*
Fluorescent Dyes / pharmacology
HeLa Cells
Humans
Infrared Rays
Mitochondria / chemistry*
Mitochondria / drug effects
Molecular Structure
Optical Imaging*
Structure-Activity Relationship

Substances

Carbocyanines
Fluorescent Dyes