Changes in Renal Peritubular Capillaries in Canine and Feline Chronic Kidney Disease

R Nakamura; A Yabuki; O Ichii; H Mizukawa; N Yokoyama; O Yamato

doi:10.1016/j.jcpa.2018.03.004

Changes in Renal Peritubular Capillaries in Canine and Feline Chronic Kidney Disease

J Comp Pathol. 2018 Apr:160:79-83. doi: 10.1016/j.jcpa.2018.03.004.

Authors

R Nakamura¹, A Yabuki², O Ichii³, H Mizukawa⁴, N Yokoyama⁵, O Yamato¹

Affiliations

¹ Laboratory of Veterinary Clinical Pathology, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan.
² Laboratory of Veterinary Clinical Pathology, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan. Electronic address: yabu@vet.kagoshima-u.ac.jp.
³ Laboratory of Anatomy, Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
⁴ Division of Environmental Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
⁵ Laboratory of Veterinary Internal Medicine, Department of Clinical Sciences, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.

PMID: 29729724
DOI: 10.1016/j.jcpa.2018.03.004

Abstract

Renal capillary rarefaction is a crucial event that leads to tubulointerstitial damage during the progression of chronic kidney disease (CKD). In the present study, changes in CD34-positive renal capillaries were investigated in dogs and cats with CKD. A significant decrease in CD34-positive capillaries was observed in canine diseased kidneys, even at the early stage of disease. In cats, CD34-positive capillaries were well preserved in the diseased kidneys, with no link to the severity of CKD. Renal capillary rarefaction might be a trigger event that leads to the progression of CKD in dogs, rather than in cats.

Keywords: capillary rarefaction; cat; chronic kidney disease; dog.

MeSH terms

Animals
Capillaries / pathology
Cat Diseases / pathology*
Cats
Dog Diseases / pathology*
Dogs
Renal Insufficiency, Chronic / veterinary*