Intestinal Stem Cells Live Off the Fat of the Land

Derek A G Barisas; Thaddeus S Stappenbeck

doi:10.1016/j.stem.2018.04.018

Intestinal Stem Cells Live Off the Fat of the Land

Cell Stem Cell. 2018 May 3;22(5):611-612. doi: 10.1016/j.stem.2018.04.018.

Authors

Derek A G Barisas¹, Thaddeus S Stappenbeck²

Affiliations

¹ Department of Pathology and Immunology, Washington University Medical School, Saint Louis, MO 63110, USA.
² Department of Pathology and Immunology, Washington University Medical School, Saint Louis, MO 63110, USA. Electronic address: stappenb@wustl.edu.

PMID: 29727673
DOI: 10.1016/j.stem.2018.04.018

Abstract

In this issue of Cell Stem Cell, Mihaylova et al. (2018) show that short-term fasting increases serum levels of long-chain fatty acids, presumably derived from the host. This effect in turn can rescue age-related phenotypes that occur in intestinal epithelial stem cells.

Publication types

Comment

MeSH terms

Fasting*
Fatty Acids
Homeostasis
Lipid Metabolism*
Stem Cells

Substances

Fatty Acids

Grants and funding

T32 GM007200/GM/NIGMS NIH HHS/United States