(IR)Factor for NAIP Expression

Sivapriya Kailasan Vanaja; Vijay A K Rathinam

doi:10.1016/j.cell.2018.04.022

(IR)Factor for NAIP Expression

Cell. 2018 May 3;173(4):817-819. doi: 10.1016/j.cell.2018.04.022.

Authors

Sivapriya Kailasan Vanaja¹, Vijay A K Rathinam²

Affiliations

¹ Department of Immunology, UConn Health School of Medicine, 263 Farmington Ave., Farmington, CT 06030, USA.
² Department of Immunology, UConn Health School of Medicine, 263 Farmington Ave., Farmington, CT 06030, USA. Electronic address: rathinam@uchc.edu.

PMID: 29727669
DOI: 10.1016/j.cell.2018.04.022

Abstract

IRF8 is a master transcription factor for immune cell development. In this issue, Karki et al. reveal that IRF8 governs the constitutive expression of genes encoding for NAIP proteins that are critical for the innate immune sensing of bacteria.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Cell Differentiation
Gene Expression Regulation
Inflammasomes*
Interferon Regulatory Factors / genetics
Neuronal Apoptosis-Inhibitory Protein / genetics*

Substances

Inflammasomes
Interferon Regulatory Factors
Neuronal Apoptosis-Inhibitory Protein