Ant Lion Optimization algorithm for kidney exchanges

PLoS One. 2018 May 3;13(5):e0196707. doi: 10.1371/journal.pone.0196707. eCollection 2018.

Abstract

The kidney exchange programs bring new insights in the field of organ transplantation. They make the previously not allowed surgery of incompatible patient-donor pairs easier to be performed on a large scale. Mathematically, the kidney exchange is an optimization problem for the number of possible exchanges among the incompatible pairs in a given pool. Also, the optimization modeling should consider the expected quality-adjusted life of transplant candidates and the shortage of computational and operational hospital resources. In this article, we introduce a bio-inspired stochastic-based Ant Lion Optimization, ALO, algorithm to the kidney exchange space to maximize the number of feasible cycles and chains among the pool pairs. Ant Lion Optimizer-based program achieves comparable kidney exchange results to the deterministic-based approaches like integer programming. Also, ALO outperforms other stochastic-based methods such as Genetic Algorithm in terms of the efficient usage of computational resources and the quantity of resulting exchanges. Ant Lion Optimization algorithm can be adopted easily for on-line exchanges and the integration of weights for hard-to-match patients, which will improve the future decisions of kidney exchange programs. A reference implementation for ALO algorithm for kidney exchanges is written in MATLAB and is GPL licensed. It is available as free open-source software from: https://github.com/SaraEl-Metwally/ALO_algorithm_for_Kidney_Exchanges.

MeSH terms

  • ABO Blood-Group System / immunology
  • Algorithms*
  • HLA Antigens / immunology
  • Histocompatibility Testing
  • Histocompatibility*
  • Humans
  • Kidney Failure, Chronic / surgery
  • Kidney Transplantation*
  • Living Donors / supply & distribution*
  • Software*
  • Stochastic Processes
  • Tissue and Organ Procurement / methods*
  • Tissue and Organ Procurement / organization & administration

Substances

  • ABO Blood-Group System
  • HLA Antigens

Grants and funding

The author(s) received no specific funding for this work.