Abstract
We demonstrate that a donut-shaped surface pattern consisting of a central hydrophobic region and a surrounding hydrophilic region simultaneously concentrates and desalts a solution of neuropeptides with a high salt content. Our approach greatly simplifies the sample preparation process for MALDI mass spectrometry.
MeSH terms
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Angiotensin I / chemistry
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Bradykinin / analogs & derivatives
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Bradykinin / chemistry
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Corticotropin-Like Intermediate Lobe Peptide / chemistry
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Gold / chemistry
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Hydrophobic and Hydrophilic Interactions
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Kinetics
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Limit of Detection
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Models, Chemical
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Neuropeptides / chemistry*
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Saline Waters / chemistry*
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Silicon / chemistry
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Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / instrumentation
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Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods*
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Sulfhydryl Compounds / chemistry
Substances
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Neuropeptides
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Sulfhydryl Compounds
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bradykinin, des-Arg(9)-
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n-octadecyl mercaptan
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Corticotropin-Like Intermediate Lobe Peptide
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Gold
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Angiotensin I
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Bradykinin
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Silicon