Focused ultrasound with microbubbles induces sterile inflammatory response proportional to the blood brain barrier opening: Attention to experimental conditions

Zsofia I Kovacs; Scott R Burks; Joseph A Frank

doi:10.7150/thno.24181

Focused ultrasound with microbubbles induces sterile inflammatory response proportional to the blood brain barrier opening: Attention to experimental conditions

Theranostics. 2018 Mar 8;8(8):2245-2248. doi: 10.7150/thno.24181. eCollection 2018.

Authors

Zsofia I Kovacs¹, Scott R Burks¹, Joseph A Frank^{1

2}

Affiliations

¹ Frank Laboratory, Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, MD 20892.
² National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892.

Abstract

This editorial highlights the findings of McMahon [1] and demonstrates the need for careful attention to experimental conditions that influence microbubble concentration and pharmacokinetics contributed to focused ultrasound-induced blood brain barrier opening and sterile inflammation.

Publication types

Editorial
Research Support, N.I.H., Intramural
Comment

MeSH terms

Attention
Blood-Brain Barrier*
Humans
Inflammation
Microbubbles*
Permeability