Impact of MCT1 Haploinsufficiency on the Mouse Retina

Neal S Peachey; Minzhong Yu; John Y S Han; Sylvain Lengacher; Pierre J Magistretti; Luc Pellerin; Nancy J Philp

doi:10.1007/978-3-319-75402-4_46

Impact of MCT1 Haploinsufficiency on the Mouse Retina

Adv Exp Med Biol. 2018:1074:375-380. doi: 10.1007/978-3-319-75402-4_46.

Authors

Neal S Peachey^{1

2

3}, Minzhong Yu^{4

5}, John Y S Han⁶, Sylvain Lengacher⁷, Pierre J Magistretti^{7

8}, Luc Pellerin⁹, Nancy J Philp⁶

Affiliations

¹ Louis Stokes Cleveland VA Medical Center, Cleveland, OH, USA. neal.peachey@va.gov.
² Cole Eye Institute, Cleveland Clinic, Cleveland, OH, USA. neal.peachey@va.gov.
³ Department of Ophthalmology, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA. neal.peachey@va.gov.
⁴ Cole Eye Institute, Cleveland Clinic, Cleveland, OH, USA.
⁵ Department of Ophthalmology, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA.
⁶ Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA.
⁷ Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
⁸ Division of Biological and Environmental Sciences and Engineering, King Abdullah University of Science and Technology (KAUST), Thuwal, KSA, Saudi Arabia.
⁹ Department of Physiology, University of Lausanne, Lausanne, Switzerland.

Abstract

The monocarboxylate transporter 1 (MCT1) is highly expressed in the outer retina, suggesting that it plays a critical role in photoreceptors. We examined MCT1 ^+/- heterozygotes, which express half of the normal complement of MCT1. The MCT1 ^+/- retina developed normally and retained normal function, indicating that MCT1 is expressed at sufficient levels to support outer retinal metabolism.

Keywords: Electroretinogram; Lactate; MCT1; Retina; Transgenic mice.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Animals
Electroretinography
Energy Metabolism
Evoked Potentials, Visual
Heterozygote
Lactates / metabolism
Mice
Mice, Inbred C57BL
Mice, Transgenic
Monocarboxylic Acid Transporters / deficiency*
Monocarboxylic Acid Transporters / genetics
Monocarboxylic Acid Transporters / metabolism
Motor Neurons / metabolism
Oligodendroglia / metabolism
Photoreceptor Cells, Vertebrate / metabolism*
Retina / metabolism*
Retinal Bipolar Cells / metabolism
Symporters / deficiency*
Symporters / genetics
Symporters / metabolism

Substances

Lactates
Monocarboxylic Acid Transporters
Symporters
monocarboxylate transport protein 1

Abstract

Publication types

MeSH terms

Substances

Grants and funding