Protective effects against tumors and infection by interleukin-27 through promotion of expansion and differentiation of hematopoietic stem cells into myeloid progenitors

Naoko Orii; Izuru Mizoguchi; Yukino Chiba; Hideaki Hasegawa; Mio Ohashi; Mingli Xu; Taro Nagai; Nakaba Ochiai; Yuki Mochizuki; Toshiyuki Owaki; Takayuki Yoshimoto

doi:10.1080/2162402X.2017.1421892

Protective effects against tumors and infection by interleukin-27 through promotion of expansion and differentiation of hematopoietic stem cells into myeloid progenitors

Oncoimmunology. 2018 Jan 15;7(5):e1421892. doi: 10.1080/2162402X.2017.1421892. eCollection 2018.

Authors

Affiliations

¹ Department of Immunoregulation, Institute of Medical Science, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo, Japan.
² Department of Immunology, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo, Japan.

Abstract

Interleukin (IL)-27 is a multifunctional cytokine that belongs to the IL-6/IL-12 family and has potent antitumor activity through various mechanisms. Our novel findings indicate that IL-27 directly acts on hematopoietic stem cells and promotes their expansion and differentiation into myeloid progenitors to control infection and to eradicate tumors.

Keywords: IL-27; antitumor activity; emergency myelopoiesis; hematopoietic stem cells; myeloid progenitors.

Publication types

Research Support, Non-U.S. Gov't

Grants and funding

Grant-in-Aid forScientific Research from the Ministry of Education, Culture, Sports, Science, and Technology, Japan Research Grant from Princess Takamatsu Cancer Research Fund Private University Strategic Research Based Project from the Ministry of Education, Culture, Sports, Science, and Technology, Japan.