Prenatal therapy for fetal cardiac disorders

J Matern Fetal Neonatal Med. 2019 Nov;32(22):3871-3881. doi: 10.1080/14767058.2018.1472224. Epub 2018 May 15.

Abstract

Fetal cardiac abnormalities are some of the commonest congenital disorders seen in prenatal life. They can be anatomical or functional and can develop de novo or as a consequence of either maternal or fetal disease. Untreated, morbidity and mortality rates are high for hypoplastic left heart disorders and for some fetal tachy and bradyarrhythmias. Optimum management strategies are often not clear because of the lack of knowledge about the precise natural history of some of these conditions. Prenatal therapy ranges from invasive fetal cardiac intervention to maternal administration of drugs for transplacental transfer to the fetus. This comprehensive review covers many fetal cardiac disorders and various prenatal therapeutic options that are available.

Keywords: Fetal cardiac intervention; aortic stenosis; fetal dysrhythmias; hypoplastic left heart syndrome; pulmonary stenosis.

Publication types

  • Review

MeSH terms

  • Cardiovascular Surgical Procedures / methods
  • Female
  • Fetal Diseases / diagnosis
  • Fetal Diseases / therapy*
  • Fetal Heart / diagnostic imaging
  • Fetal Heart / surgery
  • Fetal Therapies / methods*
  • Fetal Therapies / standards
  • Fetoscopy
  • Heart Defects, Congenital / diagnosis
  • Heart Defects, Congenital / therapy*
  • Humans
  • Pregnancy
  • Prenatal Care / methods
  • Prenatal Diagnosis / methods
  • Prenatal Diagnosis / standards