The sum-frequency generation (SFG) in potassium dihydrogen phosphate (KDP) powder with μm-grade particle size is successfully demonstrated under various experimental conditions. Two focused beams of 870 nm and 1369 nm are used for SFG excitation. SFG is observed under different excitation energies. The SFG intensity shows isotropy with different observation azimuths. The intersection angle between two excitation beams is not limited by conventional phase-matching conditions, and it owns the flexibility of a very large allowed range, e.g., it can be 0°∼100° in this work. The polarization combination of excitation beams is not limited either. Thanks to the non-toxicity, low price, and low SFG threshold properties of KDP material and the optical flexibility, this powder SFG technology is a versatile method and is expected to be applied to various situations of optical alignment, e.g., surface SFG, four-wave mixing, coherent anti-Stokes Raman spectroscopy, multi-color laser excitation, etc. The effect of potential powder SFG-assisted optical alignments is also discussed. Extension of this method to multi-beams, tight focusing beams, and plasmonic polariton devices is proposed.