Coordinated out, pendant in! Exchange of coordinated for pendant amino groups is achieved by the complex cation 1. The incoming group attacks the concave and convex positions with the same rate and always adopts the same conformation as the leaving group. However, this "conformational memory" is an inexorable consequence of well-known and dependable concepts: the principle of microscopic reversibility and the induction of chirality in prochiral reagents.
Keywords: Asymmetric synthesis; Chirality; N ligands; P ligands; Rhodium.
© 1999 WILEY-VCH Verlag GmbH, Weinheim, Fed. Rep. of Germany.