Strobilurins: Evolution of a New Class of Active Substances

Hubert Sauter; Wolfgang Steglich; Timm Anke

doi:10.1002/(SICI)1521-3773(19990517)38:10<1328::AID-ANIE1328>3.0.CO;2-1

Strobilurins: Evolution of a New Class of Active Substances

Angew Chem Int Ed Engl. 1999 May 17;38(10):1328-1349. doi: 10.1002/(SICI)1521-3773(19990517)38:10<1328::AID-ANIE1328>3.0.CO;2-1.

Authors

Hubert Sauter¹, Wolfgang Steglich², Timm Anke³

Affiliations

¹ BASF Aktiengesellschaft Hauptlaboratorium, Forschung Fungizide, D-67056 Ludwigshafen (Germany), Fax: (+49) 621-60-21156.
² Institut für Organische Chemie der Universität, Butenandt Strasse 5-13/F, D-81377 München (Germany).
³ Fachbereich Biologie, Lehrbereich Biotechnologie, Paul-Ehrlich-Strasse, Gebäude 23, D-67663 Kaiserslautern (Germany).

Abstract

A fungus that grows on pinecones yields a compound with antifungal activity that has become the natural model for a significant innovation in crop protection. Variation and optimization of the lead structure of strobilurin A (1) and selection of derivatives which fulfill all practical requirements, for example, kresoxim-methyl (2), led to an exciting and pan-industrial competition for the development of the strobilurines as a new, highly active, and broadly applicable class of fungicides-a fascinating success story.

Keywords: Active substance research; Fungicides; Natural products; Strobilurins; Structure-activity relationships.

Publication types

Review