Organocatalyzed Synthesis of [3.2.1] Bicyclooctanes

Ignacio E Tobal; Alejandro M Roncero; Narciso M Garrido; Isidro S Marcos; David Díez

doi:10.3390/molecules23051039

Organocatalyzed Synthesis of [3.2.1] Bicyclooctanes

Molecules. 2018 Apr 28;23(5):1039. doi: 10.3390/molecules23051039.

Authors

Ignacio E Tobal¹, Alejandro M Roncero², Narciso M Garrido³, Isidro S Marcos⁴, David Díez⁵

Affiliations

¹ Departamento de Química Orgánica, Universidad de Salamanca, Plaza de los Caídos 1⁻5, 37008 Salamanca, Spain. ignaciotobal@usal.es.
² Departamento de Química Orgánica, Universidad de Salamanca, Plaza de los Caídos 1⁻5, 37008 Salamanca, Spain. alexmaron@usal.es.
³ Departamento de Química Orgánica, Universidad de Salamanca, Plaza de los Caídos 1⁻5, 37008 Salamanca, Spain. nmg@usal.es.
⁴ Departamento de Química Orgánica, Universidad de Salamanca, Plaza de los Caídos 1⁻5, 37008 Salamanca, Spain. ismarcos@usal.es.
⁵ Departamento de Química Orgánica, Universidad de Salamanca, Plaza de los Caídos 1⁻5, 37008 Salamanca, Spain. ddm@usal.es.

Abstract

Organocatalysis constitutes one of the main research areas in organic chemistry from the last two decades. This chemistry has been applied to the synthesis of many natural products and structures in a manner that reduces the residues and so the ecological impact. In this review, we consider the work that has been done for the synthesis of bicyclo[3.2.1]octane framework. This structure is present in many natural products with very important biological activities.

Keywords: bicycle; bicyclo[3.2.1]; organocatalysis.

Publication types

Review

MeSH terms

Biological Products / chemistry*
Catalysis
Cyclooctanes / chemical synthesis*
Cyclooctanes / chemistry
Molecular Structure
Organic Chemistry Phenomena
Stereoisomerism

Substances

Biological Products
Cyclooctanes