Angiogenesis is crucial for tumor growth and metastasis. Recent studies revealed that tumor cells promote angiogenesis by secreting extracellular vesicles, which can be captured by endothelial cells. These tumor-derived extracellular vesicles carry microRNAs, long non-coding RNAs, and proteins, which activate pro-angiogenic signaling in endothelial cells. In this review, we will summarize the roles of tumor-derived extracellular vesicles in angiogenesis and the underlying molecular mechanisms.
Keywords: Angiogenesis; Endothelial cells; Extracellular vesicles.
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