Turning Cold Tumors Hot by Blocking TGF-β

Xavier Romero Ros; Louis Vermeulen

doi:10.1016/j.trecan.2018.03.005

Turning Cold Tumors Hot by Blocking TGF-β

Trends Cancer. 2018 May;4(5):335-337. doi: 10.1016/j.trecan.2018.03.005. Epub 2018 Mar 30.

Authors

Xavier Romero Ros¹, Louis Vermeulen²

Affiliations

¹ Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Cancer Center Amsterdam and Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.
² Laboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Cancer Center Amsterdam and Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands. Electronic address: l.vermeulen@amc.uva.nl.

PMID: 29709256
DOI: 10.1016/j.trecan.2018.03.005

Abstract

Novel immune therapeutic tools are rapidly expanding the anticancer arsenal. Despite this progress, patients with colorectal cancer (CRC) that spreads to vital parts of the body still have a dismal outcome. Transforming growth factor-β (TGF-β) plays a pivotal role in the development of CRC and metastasis. Important new work by Tauriello and colleagues has revealed that inhibition of TGF-β prevents tumor metastasis by enhancing a cytotoxic T cell response, suggesting that TGF-β inhibition is a promising pro-immunogenic therapy.

Keywords: CMS4; TGF-β; colorectal cancer; immunotherapy; mesenchymal subtype; metastasis.

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MeSH terms

Colonic Neoplasms
Colorectal Neoplasms
Humans
Immune Evasion*
Signal Transduction
Transforming Growth Factor beta*

Substances

Transforming Growth Factor beta