Antinuclear Antibody-Positive Juvenile Idiopathic Arthritis Despite IRAK-4 Deficiency

J Clin Immunol. 2018 May;38(4):450-453. doi: 10.1007/s10875-018-0501-3. Epub 2018 Apr 29.

Authors

Boris Hügle¹, Norman Händel², Klaus Schwarz³, Michael Borte⁴, Volker Schuster⁵

Affiliations

¹ German Center for Pediatric and Adolescent Rheumatology, Garmisch-Partenkirchen, Germany.
² Hospital for Children and Adolescents, University of Leipzig, Oststrasse 21-25, 04317, Leipzig, Germany.
³ Institute for Clinical Transfusion Medicine and Immunogenetics, University of Ulm, Ulm, Germany.
⁴ Klinik für Kinder- und Jugendmedizin, Klinikum St. Georg gGmbH, Leipzig, Germany.
⁵ Hospital for Children and Adolescents, University of Leipzig, Oststrasse 21-25, 04317, Leipzig, Germany. schv@medizin.uni-leipzig.de.

PMID: 29707745
DOI: 10.1007/s10875-018-0501-3

No abstract available

Publication types

Case Reports
Letter

MeSH terms

Anti-Inflammatory Agents / pharmacology
Anti-Inflammatory Agents / therapeutic use
Antibodies, Antinuclear / immunology*
Arthritis, Juvenile / complications
Arthritis, Juvenile / diagnosis*
Arthritis, Juvenile / drug therapy
Arthritis, Juvenile / etiology*
Autoimmunity
B-Lymphocytes / immunology
B-Lymphocytes / metabolism
Bacterial Infections / etiology
Biomarkers
Female
Humans
Immunologic Deficiency Syndromes / complications
Immunologic Deficiency Syndromes / diagnosis*
Interleukin-1 Receptor-Associated Kinases
Male
Primary Immunodeficiency Diseases

Substances

Anti-Inflammatory Agents
Antibodies, Antinuclear
Biomarkers
Interleukin-1 Receptor-Associated Kinases

Supplementary concepts

IRAK4 Deficiency