Intravenous Fish Oil Lipid Emulsion Prevents Catheter-Related Thromboses in Pediatric Patients with Intestinal Failure

Mohammad M Jami; Vrinda Bhardwaj; Russell J Merritt

doi:10.1016/j.jpeds.2018.03.029

Intravenous Fish Oil Lipid Emulsion Prevents Catheter-Related Thromboses in Pediatric Patients with Intestinal Failure

J Pediatr. 2018 Jul:198:301-303. doi: 10.1016/j.jpeds.2018.03.029. Epub 2018 Apr 26.

Authors

Mohammad M Jami¹, Vrinda Bhardwaj², Russell J Merritt³

Affiliations

¹ Division of Gastroenterology, Hepatology and Nutrition, Children's Hospital Los Angeles, Los Angeles, CA; Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA; Department of Pediatric Gastroenterology, Stanford Children's Health, Palo Alto, CA; Intestinal Rehabilitation Program, Division of Gastroenterology, Hepatology and Nutrition, Children's Hospital Los Angeles, Los Angeles, CA.
² Division of Gastroenterology, Hepatology and Nutrition, Children's Hospital Los Angeles, Los Angeles, CA; Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA.
³ Division of Gastroenterology, Hepatology and Nutrition, Children's Hospital Los Angeles, Los Angeles, CA; Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA; Intestinal Rehabilitation Program, Division of Gastroenterology, Hepatology and Nutrition, Children's Hospital Los Angeles, Los Angeles, CA. Electronic address: rmerritt@chla.usc.edu.

PMID: 29706493
DOI: 10.1016/j.jpeds.2018.03.029

Abstract

A central venous catheter is a risk factor for deep vein thrombosis. We compared the incidence of deep vein thrombosis in children with intestinal failure patients receiving soy oil lipid emulsion (n = 35) vs fish oil lipid emulsion (n = 35). Ten deep vein thrombosis occurred in the soy oil lipid emulsion group, and none in the fish oil lipid emulsion group (P < .001).

MeSH terms

Adolescent
Catheterization, Central Venous / adverse effects*
Central Venous Catheters / adverse effects*
Child
Child, Preschool
Fat Emulsions, Intravenous / therapeutic use*
Female
Fish Oils / therapeutic use*
Humans
Infant
Intestinal Diseases / therapy*
Male
Parenteral Nutrition
Retrospective Studies
Soybean Oil / therapeutic use
Venous Thrombosis / etiology
Venous Thrombosis / prevention & control*
Young Adult

Substances

Fat Emulsions, Intravenous
Fish Oils
Soybean Oil