Gonad damage is one of the major complications of chemotherapy, radiotherapy or surgery in male cancer patients. For those who wish for childbearing after treatment, it is of great significance how to protect the reproductive function of the cancer patients. The main strategy for fertility protection is to optimize the treatment protocol, hormone therapy, antioxidant therapy, and the preservation of sperm and testicular tissue. This article presents an overview on the pathogenesis of gonadal damage induced by different treatments and protection of the reproductive function of the patient.
男性恶性肿瘤的放疗、化疗与手术等治疗中，主要的并发症之一是对性腺造成的损伤。对于日后有生育意愿的男性恶性肿瘤患者，如何在治疗中保护生育功能意义重大。其中优化治疗方案、激素及抗氧化治疗和精子及睾丸组织保存为主要的保护方法。本文就男性恶性肿瘤患者不同治疗造成的性腺损伤机制及生殖功能的保护方法进行综述。.
Keywords: male; gonad damage; malignant tumor; reproductive function.