Abstract
We show that Tenascin-C, an asthma-associated extracellular matrix glycoprotein, promotes hematopoietic progenitors and suppresses the IL-5-driven maturation of murine lung eosinophils. The extracellular matrix’s regulation of in situ hematopoiesis has significant implications for targeting tissue eosinophils.
Publication types
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Letter
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cell Differentiation / genetics
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Cells, Cultured
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Eosinophils / physiology*
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Extracellular Matrix / metabolism*
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Extracellular Matrix Proteins / metabolism
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Granulocyte Precursor Cells / physiology*
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Humans
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Hypersensitivity / immunology*
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Mice
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Mice, Inbred C57BL
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Mice, Knockout
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Nerve Tissue Proteins / metabolism
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Pneumonia / immunology*
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Tenascin / genetics
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Tenascin / metabolism*
Substances
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Extracellular Matrix Proteins
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Nerve Tissue Proteins
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Tenascin
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neuronectin