Adherence to quality criteria improves concordance between transient elastography and ElastPQ for liver stiffness assessment-A multicenter retrospective study

Abstract

Background: Assessment of liver stiffness provides important diagnostic and prognostic information in patients with chronic liver disease.

Aims: To investigate whether the use of quality criteria (i) improves the concordance between transient elastography (TE) and a novel point shear wave elastography technique (ElastPQ^®) and (ii) impacts on the performance of ElastPQ^® for liver fibrosis staging using TE as the reference standard.

Methods: In this multicenter retrospective study, data of patients undergoing liver stiffness measurements (LSM) in five European centers were collected. TE was performed with FibroScan^® (Echosens, France) and ElastPQ^® with EPIQ^® or Affiniti^® systems (Philips, The Netherlands). The agreement between TE and ElastPQ^® LSMs was assessed with Lin's concordance correlation coefficient (CCC). Diagnostic performance of ElastPQ^® was assessed by the area under receiver operating characteristic (AUROC) curves.

Results: Overall, 664 patients were included: mean age: 54.8(13.5) years, main etiologies: viral hepatitis (83.1%) and NAFLD (7.5%). CCC increased significantly when LSMs with ElastPQ^® were obtained with IQR/M ≤ 30% (p < 0.001). The diagnostic performance of ElastPQ^® for fibrosis staging also increased if LSM values were obtained with IQR/M ≤ 30%.

Conclusion: Quality criteria should be followed when using ElastPQ^® for LSM, since the concordance with TE fibrosis staging was better at an ElastPQ^® IQR/M ≤ 30.

Keywords: Diagnostic performance; Liver fibrosis; Multicenter studies; Quality criteria; Shear wave elastography.