Understanding dengue virus evolution to support epidemic surveillance and counter-measure development

S Pollett; M C Melendrez; I Maljkovic Berry; S Duchêne; H Salje; D A T Cummings; R G Jarman

doi:10.1016/j.meegid.2018.04.032

Understanding dengue virus evolution to support epidemic surveillance and counter-measure development

Infect Genet Evol. 2018 Aug:62:279-295. doi: 10.1016/j.meegid.2018.04.032. Epub 2018 Apr 25.

Authors

S Pollett¹, M C Melendrez², I Maljkovic Berry², S Duchêne³, H Salje⁴, D A T Cummings⁵, R G Jarman²

Affiliations

¹ Viral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA; Marie Bashir Institute, University of Sydney, NSW, Australia; Institute for Global Health Sciences, University of California at San Francisco, CA, USA. Electronic address: simon.d.pollett.ctr@mail.mil.
² Viral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
³ Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Australia.
⁴ Institut Pasteur, Paris, France; Johns Hopkins School of Public Health, Baltimore, MD, USA.
⁵ Johns Hopkins School of Public Health, Baltimore, MD, USA; University of Florida, FL, USA.

Abstract

Dengue virus (DENV) causes a profound burden of morbidity and mortality, and its global burden is rising due to the co-circulation of four divergent DENV serotypes in the ecological context of globalization, travel, climate change, urbanization, and expansion of the geographic range of the Ae.aegypti and Ae.albopictus vectors. Understanding DENV evolution offers valuable opportunities to enhance surveillance and response to DENV epidemics via advances in RNA virus sequencing, bioinformatics, phylogenetic and other computational biology methods. Here we provide a scoping overview of the evolution and molecular epidemiology of DENV and the range of ways that evolutionary analyses can be applied as a public health tool against this arboviral pathogen.

Keywords: Dengue virus; Evolution; Molecular epidemiology; Phylogenetics.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Biological Evolution*
Dengue / epidemiology*
Dengue / virology*
Dengue Virus / genetics*
Epidemics*
Humans
Population Surveillance

Grants and funding

R01 AI114703/AI/NIAID NIH HHS/United States