In vivo and ex vivo elastic properties of brain tissues measured with ultrasound elastography

Yan-Lin Liu; Dong Liu; Liang Xu; Chen Su; Guo-Yang Li; Lin-Xue Qian; Yanping Cao

doi:10.1016/j.jmbbm.2018.04.017

In vivo and ex vivo elastic properties of brain tissues measured with ultrasound elastography

J Mech Behav Biomed Mater. 2018 Jul:83:120-125. doi: 10.1016/j.jmbbm.2018.04.017. Epub 2018 Apr 19.

Authors

Yan-Lin Liu¹, Dong Liu², Liang Xu³, Chen Su², Guo-Yang Li¹, Lin-Xue Qian⁴, Yanping Cao⁵

Affiliations

¹ Institute of Biomechanics and Medical Engineering, AML, Department of Engineering Mechanics, Tsinghua University, Beijing 100084, PR China.
² Department of Ultrasound, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, PR China.
³ Department of Neurosurgery, Beijing Haidian Hospital, Beijing 100080, PR China.
⁴ Department of Ultrasound, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, PR China. Electronic address: qianlinxue2002@163.com.
⁵ Institute of Biomechanics and Medical Engineering, AML, Department of Engineering Mechanics, Tsinghua University, Beijing 100084, PR China. Electronic address: caoyanping@tsinghua.edu.cn.

PMID: 29702328
DOI: 10.1016/j.jmbbm.2018.04.017

Abstract

Determining the mechanical properties of brain tissues is essential in the field of brain biomechanics. In this paper, we use ultrasound-based shear wave elastography to measure both in vivo and ex vivo elastic properties of brain tissues. Our results demonstrate that the shear modulus from in vivo measurements is about 47% higher than that given by the ex vivo measurements (p value = 0.0063). The change in ex vivo elastic properties within 60-min post-mortem is negligible. The results also show that within 60-min post-mortem and in a temperature range of 37-23 °C, the elastic properties of brain tissues approximately linearly depend on the temperature in both cooling and re-heating processes.

Keywords: Brain tissues; Effect of post-mortem interval; Elastic properties; In vivo and ex vivo measurements; Ultrasound elastography.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Brain / diagnostic imaging*
Elastic Modulus*
Elasticity Imaging Techniques*
Materials Testing
Rabbits
Temperature