DNA Photo-cross-linking Using Pyranocarbazole and Visible Light

Kenzo Fujimoto; Shinobu Sasago; Junichi Mihara; Shigetaka Nakamura

doi:10.1021/acs.orglett.8b00593

DNA Photo-cross-linking Using Pyranocarbazole and Visible Light

Org Lett. 2018 May 18;20(10):2802-2805. doi: 10.1021/acs.orglett.8b00593. Epub 2018 Apr 27.

Authors

Kenzo Fujimoto¹, Shinobu Sasago¹, Junichi Mihara¹, Shigetaka Nakamura¹

Affiliation

¹ Department of Advanced Science and Technology , Japan Advanced Institute of Science and Technology , Asahidai 1-1 , Nomi , Ishikawa, 923-1292 , Japan.

PMID: 29701982
DOI: 10.1021/acs.orglett.8b00593

Abstract

This report presents a novel photo-cross-linker that can cross-link to pyrimidines in nucleic acids under visible light irradiation (λ > 400 nm). This method offers ultrafast photo-cross-linking without any cytotoxicity due to UV irradiation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cross-Linking Reagents
DNA / chemistry*
Light
Molecular Structure
Photochemical Processes

Substances

Cross-Linking Reagents
DNA