Attitude towards ovarian tissue and oocyte cryopreservation for non-medical reasons: a cross-sectional study

Arch Gynecol Obstet. 2018 Jul;298(1):191-198. doi: 10.1007/s00404-018-4778-5. Epub 2018 Apr 26.

Abstract

Purpose: To assess the attitude towards ovarian tissue and oocyte cryopreservation for non-medical reasons.

Methods: Cross-sectional electronic survey in 248 Swiss women aged 15-35 years, nationally representative for educational level.

Results: Most women did not worry about an age-related fertility decline. Two-thirds of women would consider using hormone therapy (HT) for menopausal symptom relief although concerns about side effects and risks were still high. Acceptance of cryopreservation of oocytes (19%) or ovarian tissue (13%) for postponing fertility or menopause was generally low, but increased (37%) if both goals could be achieved with one surgery. Cryopreservation of ovarian tissue for postponing menopause was acceptable for 22% of women. Not having a suitable partner until age 35 increased the likelihood of considering postponing fertility by cryopreservation (p < 0.001) and had a stronger impact on that decision than the factor "pursuing a career" (p < 0.001).

Conclusion: More education on age-related fertility decline, menopause and HT (benefit-risk ratio) is needed. Furthermore, the political and socioeconomic discussion should focus on women's needs, especially on compatibility of career and family.

Keywords: Cryopreservation; Fertility; Hormone therapy; Oocyte; Ovarian tissue.

MeSH terms

  • Adolescent
  • Adult
  • Attitude
  • Cross-Sectional Studies
  • Cryopreservation / methods*
  • Female
  • Fertility Preservation / methods*
  • Humans
  • Oocytes / cytology
  • Oocytes / metabolism*
  • Young Adult