Abstract
A new metabolite, cyclic dipeptide, cis-(3S,8aS)-3-(3,4-dihydroxybenzyl)hexahydropyrrolo[1,2-a]pyrazine-1,4-dione, named JS-3 was isolated from Streptomyces sp. 8812 fermentation broth. Its chemical structure was established by means of spectroscopic analysis. A wide-range-screening study, which included inhibition assay of DD-carboxypeptidase/transpeptidase activity, determination of antibacterial, antifungal, and antiproliferative activities as well as free-radical scavenging was performed. To authors knowledge, this is the first isolation of such compound from natural sources and the first one from bacteria, Streptomyces.
MeSH terms
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Anti-Bacterial Agents / isolation & purification
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Anti-Bacterial Agents / pharmacology*
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Antifungal Agents / isolation & purification
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Antifungal Agents / pharmacology*
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Bacteria / drug effects
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Carboxypeptidases / antagonists & inhibitors*
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Diketopiperazines / isolation & purification
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Diketopiperazines / metabolism
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Diketopiperazines / pharmacology*
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Dipeptides / isolation & purification
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Dipeptides / metabolism
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Dipeptides / pharmacology*
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Fermentation
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Fungi / drug effects
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Peptidyl Transferases / antagonists & inhibitors*
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Streptomyces / metabolism*
Substances
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Anti-Bacterial Agents
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Antifungal Agents
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Diketopiperazines
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Dipeptides
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Peptidyl Transferases
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Carboxypeptidases