Lack of evidence that nephrolithiasis increases the risk of sialolithiasis: A longitudinal follow-up study using a national sample cohort

Hyo Geun Choi; Woojin Bang; Bumjung Park; Songyong Sim; Kyung Tae; Chang Myeon Song

doi:10.1371/journal.pone.0196659

Lack of evidence that nephrolithiasis increases the risk of sialolithiasis: A longitudinal follow-up study using a national sample cohort

PLoS One. 2018 Apr 26;13(4):e0196659. doi: 10.1371/journal.pone.0196659. eCollection 2018.

Authors

Hyo Geun Choi¹, Woojin Bang², Bumjung Park¹, Songyong Sim³, Kyung Tae⁴, Chang Myeon Song⁴

Affiliations

¹ Department of Otolaryngology-Head and Neck Surgery, Hallym University College of Medicine, Anyang, Korea.
² Department of Urology, Hallym University Sacred Heart Hospital, Anyang, Korea.
³ Department of Statistics, Hallym University, Chuncheon, Korea.
⁴ Department of Otolaryngology-Head and Neck Surgery, Hanyang University College of Medicine, Seoul, Korea.

Abstract

Objective: The objective of this study was to evaluate the risk of sialolithiasis in nephrolithiasis patients.

Methods: Using data from the national cohort study from the Korean Health Insurance Review and Assessment Service, we selected 24,038 patients with nephrolithiasis. The control group consisted of 96,152 participants without nephrolithiasis who were matched 1:4 by age, sex, income, region of residence, diabetes, hypertension, and dyslipidemia. The incidence of sialolithiasis in the two groups was compared, with a follow-up period of up to 12 years. The crude and adjusted hazard ratio (HR) of nephrolithiasis to sialolithiasis was analyzed with a Cox-proportional hazard regression model.

Results: The rates of sialolithiasis in the nephrolithiasis group and the control group were not significantly different (0.08% vs. 0.1%, P = 0.447). The crude and adjusted hazard ratios of nephrolithiasis to sialolithiasis were not statistically significant (crude HR = 0.82, 95% confidence interval [CI] = 0.50-1.35, P = 0.448; adjusted HR = 0.81, 95% CI = 0.49-1.33, P = 0.399). Subgroup analyses according to age and sex also failed to reveal statistical significance.

Conclusion: There is no evidence of an increased risk of sialolithiasis associated with nephrolithiasis. We suggest that routine evaluation for sialolithiasis in all patients with nephrolithiasis is not necessary.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Databases, Factual
Female
Follow-Up Studies
Humans
Incidence
Kidney Calculi / complications
Kidney Calculi / diagnosis
Kidney Calculi / pathology*
Longitudinal Studies
Male
Middle Aged
Proportional Hazards Models
Risk Factors
Salivary Gland Calculi / epidemiology
Salivary Gland Calculi / etiology
Salivary Gland Calculi / pathology*

Grants and funding

This work was supported by the research fund of Hanyang University (HY-2017) to Chang Myeon Song. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.