Frontal Lobe Cavernous Malformations in Pediatric Patients: Clinical Features and Surgical Outcomes

J Child Neurol. 2018 Jul;33(8):512-518. doi: 10.1177/0883073818768156. Epub 2018 Apr 26.

Abstract

The purpose of this study is to investigate the clinical manifestations, surgical treatment, and neurologic outcomes of frontal lobe cavernous malformations in children. A retrospective analysis of 23 pediatric frontal lobe cavernous malformation patients who underwent surgical treatment in Beijing Tiantan Hospital was performed. The case series included 16 boys and 7 girls. Gross total removal without surgical mortality was achieved in all patients. The mean follow-up period after surgery was 33.1 months. Two patients who left hospital with motor deficits gradually recovered after rehabilitative treatment, and other patients were considered to be in excellent clinical condition. For symptomatic frontal lobe cavernous malformations, neurosurgical management should be the treatment of choice. Conservative treatment may be warranted in asymptomatic frontal lobe cavernous malformations, especially the deep-seated or eloquently located cases.

Keywords: cavernous malformation; clinical features; frontal lobe; pediatric; surgical treatment.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Brain / diagnostic imaging
  • Brain / pathology
  • Brain / surgery
  • Central Nervous System Neoplasms / diagnosis*
  • Central Nervous System Neoplasms / diagnostic imaging
  • Central Nervous System Neoplasms / pathology
  • Central Nervous System Neoplasms / surgery*
  • Child
  • Child, Preschool
  • Female
  • Follow-Up Studies
  • Frontal Lobe
  • Hemangioma, Cavernous, Central Nervous System / diagnosis*
  • Hemangioma, Cavernous, Central Nervous System / diagnostic imaging
  • Hemangioma, Cavernous, Central Nervous System / pathology
  • Hemangioma, Cavernous, Central Nervous System / surgery*
  • Humans
  • Infant
  • Male
  • Retrospective Studies
  • Treatment Outcome