Fine-Tuning Mitochondrial Dysfunction and Reductive Carboxylation

Christopher J Halbrook; Zeribe C Nwosu; Costas A Lyssiotis

doi:10.1016/j.tem.2018.04.002

Fine-Tuning Mitochondrial Dysfunction and Reductive Carboxylation

Trends Endocrinol Metab. 2018 Sep;29(9):599-602. doi: 10.1016/j.tem.2018.04.002. Epub 2018 Apr 23.

Authors

Christopher J Halbrook¹, Zeribe C Nwosu¹, Costas A Lyssiotis²

Affiliations

¹ Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
² Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA; Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI, USA; Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA; http://lyssiotislab.com. Electronic address: clyssiot@med.umich.edu.

PMID: 29692332
DOI: 10.1016/j.tem.2018.04.002

Abstract

Metabolic processes within cells are dynamically interconnected. If mitochondria become defective, cells must rewire their metabolism to survive. Here we highlight recent work by Gaude et al. that used a tunable model of mitochondrial dysfunction combined with metabolic tracing and in silico analyses to define these compensatory pathways.

Keywords: GAPDH; MDH1; NAD/NADH; glycolysis; redox.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Glutamine*
Glycolysis*
Mitochondria
NAD
Oxidation-Reduction

Substances

Glutamine
NAD

Abstract

Publication types

MeSH terms

Substances

Grants and funding