Over the recent years, the advent of 3D bioprinting technology has marked a milestone in osteochondral tissue engineering (TE) research. Nowadays, the traditional used techniques for osteochondral regeneration remain to be inefficient since they cannot mimic the complexity of joint anatomy and tissue heterogeneity of articular cartilage. These limitations seem to be solved with the use of 3D bioprinting which can reproduce the anisotropic extracellular matrix (ECM) and heterogeneity of this tissue. In this chapter, we present the most commonly used 3D bioprinting approaches and then discuss the main criteria that biomaterials must meet to be used as suitable bioinks, in terms of mechanical and biological properties. Finally, we highlight some of the challenges that this technology must overcome related to osteochondral bioprinting before its clinical implementation.
Keywords: 3D bioprinting; Acellular bioprinting; Bioink; Cellular bioprinting; Extracellular matrix.