Cytotoxic and glycosaminoglycan priming activities of novel 4-anilinequinazoline β-D-xylosides

Abstract

β-D-xylosides with cytotoxic aglycones have augmented cytotoxicity towards animal cells because β-D-xyloside-primed glycosaminoglycans further enhance the aglycone's cytotoxicity. In this study, we designed and synthesized different 4-anilinequinazoline β-D-xylosides and found that compounds 7-10 possessing 3-chloro-4-((3-fluorobenzyl)oxy)aniline group as in anticancer drug lapatinib also primed glycosaminoglycans and were highly cytotoxic to cancer cells.

Keywords: 4-Anilinequinazolines; Cytotoxicity; Glycosaminoglycans; β-D-xylosides.