Autophagosome Formation: Cutting the Gordian Knot at the ER

Bhawana Bissa; Vojo Deretic

doi:10.1016/j.cub.2018.03.015

Autophagosome Formation: Cutting the Gordian Knot at the ER

Curr Biol. 2018 Apr 23;28(8):R347-R349. doi: 10.1016/j.cub.2018.03.015.

Authors

Bhawana Bissa¹, Vojo Deretic²

Affiliations

¹ Autophagy Inflammation and Metabolism (AIM) Center of Biomedical Research Excellence, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE, Albuquerque, NM 87131, USA; Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE, Albuquerque, NM 87131, USA.
² Autophagy Inflammation and Metabolism (AIM) Center of Biomedical Research Excellence, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE, Albuquerque, NM 87131, USA; Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE, Albuquerque, NM 87131, USA. Electronic address: VDeretic@salud.unm.edu.

PMID: 29689207
DOI: 10.1016/j.cub.2018.03.015

Abstract

Autophagosome biogenesis and the origins of its isolation membrane have been a long-standing unresolved question, with the endoplasmic reticulum and its membrane contact sites with other organelles remaining the prime suspect. This concept has now been reinforced by recent advances uncovering roles of several ER membrane proteins in autophagosome formation.

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MeSH terms

Autophagosomes
Autophagy*
Autophagy-Related Proteins
Endoplasmic Reticulum
Membrane Proteins

Substances

Autophagy-Related Proteins
Membrane Proteins

Abstract

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MeSH terms

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