Advances on CD8+ Treg Cells and Their Potential in Transplantation

Séverine Bézie; Ignacio Anegon; Carole Guillonneau

doi:10.1097/TP.0000000000002258

Advances on CD8+ Treg Cells and Their Potential in Transplantation

Transplantation. 2018 Sep;102(9):1467-1478. doi: 10.1097/TP.0000000000002258.

Authors

Séverine Bézie^{1

2

3}, Ignacio Anegon^{1

2

3}, Carole Guillonneau^{1

2

3}

Affiliations

¹ Centre de Recherche en Transplantation et Immunologie, INSERM, Université de Nantes, Nantes, France.
² Institut de Transplantation Urologie Néphrologie (ITUN), CHU Nantes, Nantes, France.
³ LabEx IGO "Immunotherapy, Graft, Oncology", Nantes, France.

PMID: 29688996
DOI: 10.1097/TP.0000000000002258

Abstract

Although cluster of differentiation (CD)8 regulatory T (Treg) cells have been in the last 20 years more studied since evidences of their role in tolerance as been demonstrated in transplantation, autoimmune diseases and cancer, their characteristics are still controversial. In this review, we will focus on recent advances on CD8 Treg cells and description of a role for CD8 Treg cells in tolerance in both solid organ transplantation and graft-versus-host disease and their potential for clinical trials.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Adoptive Transfer
Animals
Graft Rejection / immunology*
Graft Rejection / metabolism
Graft Rejection / prevention & control
Graft Survival
Graft vs Host Disease / immunology*
Graft vs Host Disease / metabolism
Graft vs Host Disease / prevention & control
Humans
Organ Transplantation / adverse effects*
Phenotype
Signal Transduction
T-Lymphocytes, Regulatory / immunology*
T-Lymphocytes, Regulatory / metabolism
T-Lymphocytes, Regulatory / transplantation
Transplantation Tolerance*
Treatment Outcome