Abstract
A high-yield synthesis of some novel isatin-3-acylhydrazones on the base of 5-ethylisatin derivatives and Girard's reagent T is described. Antimicrobial activity preliminary SAR study of both 1-benzylated isatins and water-soluble hydrazones was established. The most active against Staphylococcus aureus and Bacillus cereus are ammonium salts bearing 3,4-dichloro- or 4-CF3 substituents in benzyl fragment.
Keywords:
antimicrobial activity; crystal structure; hydrazides; hydrazones; isatin.
© 2018 Wiley-VHCA AG, Zurich, Switzerland.
MeSH terms
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Anti-Bacterial Agents / chemical synthesis
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology*
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Bacillus cereus / drug effects*
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Dose-Response Relationship, Drug
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Hydrazones / chemical synthesis
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Hydrazones / chemistry
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Hydrazones / pharmacology*
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Isatin / chemical synthesis
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Isatin / chemistry
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Isatin / pharmacology*
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Microbial Sensitivity Tests
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Molecular Structure
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Solubility
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Staphylococcus aureus / drug effects*
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Structure-Activity Relationship
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Water / chemistry*
Substances
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Anti-Bacterial Agents
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Hydrazones
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Water
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Isatin