Synthesis of novel quinolinomatrine derivatives and their insecticidal/acaricidal activities

Bioorg Med Chem Lett. 2018 Jun 1;28(10):1753-1757. doi: 10.1016/j.bmcl.2018.04.029. Epub 2018 Apr 12.

Abstract

In continuation of our program to discover natural product-based pesticidal agents, a series of new quinolinomatrine derivatives were prepared. Especially three-dimensional structures of five compounds were unambiguously determined by single-crystal X-ray diffraction. Among them, 21-chloroquinolinomatrine exhibited good insecticidal and acaricidal activities against two crop-threatening insect pests, Mythimna separata and Tetranychus cinnabarinus. Their structure-activity relationships were also discussed.

Keywords: Acaricidal activity; Insecticidal activity; Matrine; Quinoline.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acaricides / chemical synthesis
  • Acaricides / chemistry
  • Acaricides / pharmacology*
  • Alkaloids / chemical synthesis
  • Alkaloids / chemistry
  • Alkaloids / pharmacology*
  • Animals
  • Dose-Response Relationship, Drug
  • Insecticides / chemical synthesis
  • Insecticides / chemistry
  • Insecticides / pharmacology*
  • Lepidoptera / drug effects*
  • Matrines
  • Molecular Structure
  • Quinolines / chemical synthesis
  • Quinolines / chemistry
  • Quinolines / pharmacology*
  • Quinolizines / chemical synthesis
  • Quinolizines / chemistry
  • Quinolizines / pharmacology*
  • Structure-Activity Relationship
  • Tetranychidae / drug effects*

Substances

  • Acaricides
  • Alkaloids
  • Insecticides
  • Quinolines
  • Quinolizines
  • Matrines