Abstract
In continuation of our program to discover natural product-based pesticidal agents, a series of new quinolinomatrine derivatives were prepared. Especially three-dimensional structures of five compounds were unambiguously determined by single-crystal X-ray diffraction. Among them, 21-chloroquinolinomatrine exhibited good insecticidal and acaricidal activities against two crop-threatening insect pests, Mythimna separata and Tetranychus cinnabarinus. Their structure-activity relationships were also discussed.
Keywords:
Acaricidal activity; Insecticidal activity; Matrine; Quinoline.
Copyright © 2018 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acaricides / chemical synthesis
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Acaricides / chemistry
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Acaricides / pharmacology*
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Alkaloids / chemical synthesis
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Alkaloids / chemistry
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Alkaloids / pharmacology*
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Animals
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Dose-Response Relationship, Drug
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Insecticides / chemical synthesis
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Insecticides / chemistry
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Insecticides / pharmacology*
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Lepidoptera / drug effects*
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Matrines
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Molecular Structure
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Quinolines / chemical synthesis
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Quinolines / chemistry
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Quinolines / pharmacology*
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Quinolizines / chemical synthesis
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Quinolizines / chemistry
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Quinolizines / pharmacology*
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Structure-Activity Relationship
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Tetranychidae / drug effects*
Substances
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Acaricides
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Alkaloids
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Insecticides
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Quinolines
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Quinolizines
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Matrines