Down syndrome and mild kidney dysfunction

Pediatr Int. 2018 Apr;60(4):391-393. doi: 10.1111/ped.13525.

Abstract

Few studies have evaluated kidney function in children with Down syndrome (DS) in detail. This study investigated kidney function in pediatric DS patients without complications that affect kidney function. Creatinine (Cr)- and cystatin C (cysC)-based estimated glomerular filtration rate (eGFR) were measured in a cohort of Japanese DS patients. The kidney function in these children with DS was approximately 80% that of the healthy Japanese children, suggesting that children with DS have smaller kidneys or a lower number of glomeruli than children without DS.

Keywords: Down syndrome; children; glomerular filtration rate; kidney function.

MeSH terms

  • Adolescent
  • Case-Control Studies
  • Child
  • Child, Preschool
  • Down Syndrome / complications*
  • Down Syndrome / physiopathology
  • Female
  • Humans
  • Japan
  • Male
  • Reference Values
  • Renal Insufficiency / diagnosis
  • Renal Insufficiency / etiology*
  • Renal Insufficiency / physiopathology
  • Retrospective Studies
  • Severity of Illness Index