1 I Clinica Medica, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy. Department of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences, Sapienza University of Rome, Rome, Italy. Department of Experimental Medicine, Section of Medical Pathophysiology, Endocrinology and Nutrition, Sapienza University, Rome, Italy. Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy. These authors contributed equally: Daniele Pastori, Francesco Baratta.