β-tricalcium phosphate composite ceramics with high compressive strength, enhanced osteogenesis and inhibited osteoclastic activities

Abstract

β-tricalcium phosphate (β-TCP) is well known as a resorbable bone repair material due to its inherent excellent biocompatibility and osteoconductivity. However, β-TCP is encountered with osteostimulation-deficiency and poor mechanical strength because of poor sinterability. Herein, we prepared novel β-TCP composite ceramics (TCP/SPGs) by introducing strontium-containing phosphate-based glass (SPG; 45P₂O₅-32SrO-23Na₂O) as sintering additive. The SPG helped to achieve efficient liquid-phase sintering of β-TCP at 1100 °C. The compressive strength of TCP/SPGs with 15 wt.% SPG (TCP/SPG15) was 2.65 times as high as that of plain β-TCP ceramic. The SPG reacted with β-TCP, and the Sr²⁺ and Na²⁺ from SPG replaced Ca²⁺ in the lattice structure of β-TCP, enabling the sustained release of strontium from TCP/SPGs. In vitro cytological test indicated that TCP/SPGs with certain amount of SPG were highly biocompatible, and noticeably promoted osteogenesis, and inhibited osteoclastic activities. Our results suggested that the TCP/SPG15 might be potential high-strength bone grafts used for bone defect repair, especially in the osteoporotic condition.

Keywords: Biological behavior; Bone graft; Calcium phosphate; Compressive strength; Strontium.