Interactions between amyloid β peptide and lipid membranes

Zheng Niu; Zhengfeng Zhang; Weijing Zhao; Jun Yang

doi:10.1016/j.bbamem.2018.04.004

Interactions between amyloid β peptide and lipid membranes

Biochim Biophys Acta Biomembr. 2018 Sep;1860(9):1663-1669. doi: 10.1016/j.bbamem.2018.04.004. Epub 2018 Apr 18.

Authors

Zheng Niu¹, Zhengfeng Zhang¹, Weijing Zhao¹, Jun Yang²

Affiliations

¹ Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Center for Magnetic Resonance, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, 430071 Wuhan, PR China.
² Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Center for Magnetic Resonance, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, 430071 Wuhan, PR China. Electronic address: yangjun@wipm.ac.cn.

PMID: 29679539
DOI: 10.1016/j.bbamem.2018.04.004

Abstract

The presence of amyloid plaques in the brain is a typical characteristic of Alzheimer's disease (AD). Amyloid plaques are formed from the deposits of aggregated amyloid β peptide (Aβ). The toxicity induced by Aβ aggregates is correlated with Aβ-membrane interactions. The mutual influences between aggregation and membranes are complicated and unclear. In recent years advanced experiments and findings are emerging to give us more detailed information on Aβ-membrane interactions. In this review, we mainly focus on the Aβ-membrane interactions and membrane-induced Aβ structures. The mechanism of Aβ-membrane interactions is also summarized, which provides insights into the prevention and treatment of AD.

Keywords: Alzheimer's disease; Fibrillation; Membrane disruption; Phospholipids; Solid-state nuclear magnetic resonance; β-Amyloid peptide.

Publication types

Review