Lomentospora prolificans fungemia in hematopoietic stem cell transplant patients: First report in South America and literature review

Transpl Infect Dis. 2018 Aug;20(4):e12908. doi: 10.1111/tid.12908. Epub 2018 May 9.

Abstract

Lomentospora prolificans is a filamentous fungus and an emerging pathogen in immunocompromised patients. It is encountered most commonly in Australia, Spain, and USA. We described the first case of Lomentospora prolificans fungemia in South America. The patient was a hematopoietic stem cell transplantation (HSCT) recipient who developed the infection 37 days after stem cells infusion. In addition, we performed a literature review of invasive lomentosporiosis in HSCT patients.

Keywords: Lomentospora prolificans; Brazil; Fungemia; stem cell transplantation.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adolescent
  • Antifungal Agents / therapeutic use
  • Cord Blood Stem Cell Transplantation / adverse effects
  • Cord Blood Stem Cell Transplantation / methods
  • DNA, Fungal / isolation & purification
  • Fungemia / diagnostic imaging
  • Fungemia / drug therapy
  • Fungemia / immunology
  • Fungemia / microbiology*
  • Granulomatous Disease, Chronic / surgery
  • Hematopoietic Stem Cell Transplantation / adverse effects*
  • Hematopoietic Stem Cell Transplantation / methods
  • Humans
  • Immunocompromised Host*
  • Male
  • Radiography
  • Scedosporium / genetics
  • Scedosporium / isolation & purification
  • Scedosporium / pathogenicity*
  • South America
  • Transplantation Conditioning / adverse effects*
  • Transplantation Conditioning / methods

Substances

  • Antifungal Agents
  • DNA, Fungal

Associated data

  • GENBANK/MG735730