Regenerative Medicine Strategies in Biomedical Implants

Curr Osteoporos Rep. 2018 Jun;16(3):236-245. doi: 10.1007/s11914-018-0441-0.

Abstract

Purpose of review: Recently, significant progress has been made in the research related to regenerative medicine. At the same time, biomedical implants in orthopedics and dentistry are facing many challenges and posing clinical concerns. The purpose of this chapter is to provide an overview of the clinical applications of current regenerative strategies to the fields of dentistry and orthopedic surgery. The main research question in this review is: What are the major advancement strategies in regenerative medicine that can be used for implant research?

Recent findings: The implant surfaces can be modified through patient-specific stem cells and plasma coatings, which may provide methods to improve osseointegration and sustainability of the implant. Overall understanding from the review suggesting that the outcome from the studies could lead to identify optimum solutions for many concerns in biomedical implants and even in drug developments as a long-term solution to orthopedic and dental patients.

Keywords: Biomedical implants; Regenerative medicine; Stem cells; Surface modifications.

Publication types

  • Review

MeSH terms

  • Arthroplasty, Replacement, Hip
  • Arthroplasty, Replacement, Knee
  • Bone-Implant Interface*
  • Dental Implants*
  • Hip Prosthesis
  • Humans
  • Joint Prosthesis*
  • Knee Prosthesis
  • Orthopedics
  • Osseointegration*
  • Osteoarthritis / surgery
  • Prostheses and Implants
  • Regenerative Medicine*
  • Spondylosis / surgery
  • Stem Cells*
  • Total Disc Replacement

Substances

  • Dental Implants