Abstract
We report voriconazole levels in an infant with disseminated Candida glabrata infection who received combination antifungal therapy and rescue voriconazole treatment. Serum and cerebrospinal fluid voriconazole levels were higher than anticipated and above target. Dose reduction did not lead to a reduction in the blood or cerebrospinal fluid levels. The patient did not exhibit identifiable drug toxicity.
Publication types
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Case Reports
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Administration, Intravenous
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Antifungal Agents / cerebrospinal fluid
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Antifungal Agents / therapeutic use*
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Candida glabrata / drug effects
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Candidiasis / cerebrospinal fluid
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Candidiasis / drug therapy*
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Drug Resistance, Fungal
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Drug Therapy, Combination
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Fatal Outcome
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Humans
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Infant
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Infant, Premature
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Male
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Meningitis / drug therapy*
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Meningitis / microbiology
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Microbial Sensitivity Tests
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Multiple Organ Failure
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Voriconazole / blood
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Voriconazole / therapeutic use*
Substances
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Antifungal Agents
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Voriconazole