Abstract
Four new gastrodin derivatives containing a trans-cinnamoyl unit (1-4) and nine known compounds (5-13) were isolated from the rhizomes of Gastrodia elata Blume. All these compounds were evaluated for their neuroprotective effects against 6-hydroxydopamine-induced cell death, and compounds 7 and 12 showed potent activities with EC50 values of 10.5 and 10.2 μM, respectively.
Keywords:
-(4-hydroxybenzyl) adenosine; Blume; Phenolics; grossamide; neuroprotective effects.
MeSH terms
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Animals
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Benzyl Alcohols / chemistry
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Cell Death / drug effects
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Cell Line
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Drug Evaluation, Preclinical / methods
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Drugs, Chinese Herbal / chemistry
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Gastrodia / chemistry*
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Glucosides / chemistry
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Magnetic Resonance Spectroscopy
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Mice
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Molecular Structure
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Neurons / drug effects
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Neuroprotective Agents / chemistry
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Neuroprotective Agents / pharmacology*
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Oxidopamine / toxicity
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Phenols / chemistry
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Phenols / pharmacology*
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Plant Extracts / chemistry
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Rhizome / chemistry
Substances
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Benzyl Alcohols
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Drugs, Chinese Herbal
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Glucosides
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Neuroprotective Agents
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Phenols
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Plant Extracts
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gastrodin
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Oxidopamine