Four new phenolic constituents from the rhizomes of Gastrodia elata Blume

Nat Prod Res. 2019 Apr;33(8):1140-1146. doi: 10.1080/14786419.2018.1460836. Epub 2018 Apr 20.

Abstract

Four new gastrodin derivatives containing a trans-cinnamoyl unit (1-4) and nine known compounds (5-13) were isolated from the rhizomes of Gastrodia elata Blume. All these compounds were evaluated for their neuroprotective effects against 6-hydroxydopamine-induced cell death, and compounds 7 and 12 showed potent activities with EC50 values of 10.5 and 10.2 μM, respectively.

Keywords: -(4-hydroxybenzyl) adenosine; Blume; Phenolics; grossamide; neuroprotective effects.

Publication types

  • Video-Audio Media

MeSH terms

  • Animals
  • Benzyl Alcohols / chemistry
  • Cell Death / drug effects
  • Cell Line
  • Drug Evaluation, Preclinical / methods
  • Drugs, Chinese Herbal / chemistry
  • Gastrodia / chemistry*
  • Glucosides / chemistry
  • Magnetic Resonance Spectroscopy
  • Mice
  • Molecular Structure
  • Neurons / drug effects
  • Neuroprotective Agents / chemistry
  • Neuroprotective Agents / pharmacology*
  • Oxidopamine / toxicity
  • Phenols / chemistry
  • Phenols / pharmacology*
  • Plant Extracts / chemistry
  • Rhizome / chemistry

Substances

  • Benzyl Alcohols
  • Drugs, Chinese Herbal
  • Glucosides
  • Neuroprotective Agents
  • Phenols
  • Plant Extracts
  • gastrodin
  • Oxidopamine