Differential activation of pro-survival pathways in response to CD40LG/IL4 stimulation in chronic lymphocytic leukaemia cells

Br J Haematol. 2019 Mar;184(5):867-869. doi: 10.1111/bjh.15197. Epub 2018 Apr 20.

Authors

Yixiang Chen^{1

2

3}, Chloé Peubez^{1

2}, Sandrine Jayne^{2

4}, Gabriella Kocsis-Fodor^{1

2}, Martin J S Dyer^{2

4}, Salvador Macip^{1

2}

Affiliations

¹ Mechanisms of Cancer and Ageing Laboratory, Department of Molecular and Cell Biology, University of Leicester, Leicester, UK.
² Ernest and Helen Scott Haematological Research Institute, University of Leicester, Leicester, UK.
³ Medical College, Henan University of Science and Technology, Luoyang, China.
⁴ Department of Cancer Studies, University of Leicester, Leicester, UK.

PMID: 29676456
DOI: 10.1111/bjh.15197

No abstract available

Keywords: CD40LG/CD154; IL4; chronic lymphocytic leukaemia; microenvironment.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

CD40 Ligand / pharmacology*
Cell Line, Tumor
Cell Survival / drug effects
Humans
Interleukin-4 / pharmacology*
Leukemia, Lymphocytic, Chronic, B-Cell / metabolism*
Leukemia, Lymphocytic, Chronic, B-Cell / pathology

Substances

IL4 protein, human
CD40 Ligand
Interleukin-4

Grants and funding

MC_U132670597/MRC_/Medical Research Council/United Kingdom